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2014-09-12 https://thelittlegiantsfoundation.org/blog/2014/09/blog-post.html monthly 0.5 2014-09-09 https://thelittlegiantsfoundation.org/blog/2014/09/little-giants-foundation-passes-torch.html monthly 0.5 2014-09-06 https://thelittlegiantsfoundation.org/blog/2014/08/koesters-take-over-little-giants.html monthly 0.5 2014-08-21 https://thelittlegiantsfoundation.org/blog/2014/08/registration-is-now-open.html monthly 0.5 2014-08-17 https://thelittlegiantsfoundation.org/blog/2014/08/koesters-take-over-board-of-directors.html monthly 0.5 2014-08-15 https://thelittlegiantsfoundation.org/blog/2014/08/extra-extra-read-all-about-it.html monthly 0.5 2014-08-07 https://thelittlegiantsfoundation.org/home-page daily 0.75 2019-04-24 https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1556120195907-TSJOMEFW94HAU4VZFZE5/20171023_084044.jpg Home page https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1556120195907-TSJOMEFW94HAU4VZFZE5/20171023_084044.jpg Home page https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1556120199937-C9G7NI1MCGVZ83O5AF00/IMG_6377+copy+copy+3.jpg Home page https://thelittlegiantsfoundation.org/home-impact daily 1.0 2024-10-14 https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1556120308356-KBRA6JC36B704T76KQCE/IMG_6377+copy+copy+3.jpg Home https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1692750151368-BR4O3JNEW2NJK48N6AUT/IMG_3407.jpg Home https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1556120642731-ANU9Y436ELMIU4WNBJI6/IMG_6377%2Bcopy%2Bcopy%2B3.jpg Home - Our Mission To bring a face and voice to SIOD and help fund the research needed to prolong these childrens’ lives. The Little Giants Foundation works with families, doctors and researchers around the world to help educate, raise awareness, and gather funding for a rare genetic life-limiting disease called Schimke Immuno-osseous Dysplasia or SIOD. https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1556119054840-YT15FJMKOA7D7LYZBG9C/20171023_084044.jpg Home - Our inspiration Emily is one of ten diagnosed in the United States and one of 50 in the world with SIOD. She is proportionate and stands 41 inches tall at 21 years of age, already surpassing the life-expectancy of this disease. She’s witty, she likes to play harmless pranks especially at school - mostly on the teachers - she loves Cheetahs and helps raise money for the cheetah conservation fund in Namibia Africa. She loves animals, fairies and all things nature and the color pink and rainbows. She’ll tell you like it is and has the heart of an old soul. Emily’s family takes each moment they get and live life to its fullest as they continually raise the bar for Emily's quality of life. https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1556121630337-0A876TKHMHRNE2XN2FOY/40566888_949771578540034_3369065852715401216_n.jpg Home - Our fight Schimke immuno-osseous dysplasia is a condition characterized by short stature, kidney disease, and a weakened immune system. It’s believed that many more children may have Schimke but the journey to a diagnosis can take years and most lose their battle from the symptoms of kidney failure, infection, or stroke before they’ve been accurately diagnosed. Research has been going on for Emily’s disease for well over a decade and this is the hope, the belief, the one thing the Koesters have been fighting for - a possibility to prolong Emily’s life, to begin to get not only an understanding of this disease, but to help others now and in the future learn about SIOD from Emily. https://thelittlegiantsfoundation.org/mission-index-impact daily 0.75 2025-05-09 https://images.squarespace-cdn.com/content/v1/59dbc7c2cf81e0c47e15482d/1509982161912-TROPQF7917INCAJZG54V/_50A4149.jpg Mission https://images.squarespace-cdn.com/content/v1/59dbc7c2cf81e0c47e15482d/1509982426921-H8N1MHM8P0PC9NE5WPP3/image-asset.jpeg Mission "Sed dictum ante a leo cursus mattis. Integer euismod, lorem sed molestie gravida, justo mauris dignissim orci, sed convallis elit ipsum at justo. Donec feugiat justo vitae mollis pretium. Suspendisse ultrices, tellus vitae varius convallis, ipsum justo commodo dui, a feugiat mauris turpis ut turpis." — Donovan Mafnas, Impact Volunteer https://thelittlegiantsfoundation.org/volunteer-index-impact daily 0.75 2025-05-09 https://images.squarespace-cdn.com/content/v1/59dbc7c2cf81e0c47e15482d/1509983042007-RTMWNU37BD3WV9M6HT4B/_50A4130.jpg Volunteer https://thelittlegiantsfoundation.org/donate-index-impact daily 0.75 2025-05-09 https://images.squarespace-cdn.com/content/v1/59dbc7c2cf81e0c47e15482d/1509386798700-GZN997HA8TMR0M009X0F/Untitled-3.jpg Donate https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1556128285892-AG348DV469XJBGS1YQDU/53028693_1057343354449522_7574350542198013952_n.jpg Donate https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/9dca5e23-1cde-49e3-bd8d-f3111888b14b/63149FF6-0EBD-425F-A0E6-9AB2AB2CA9FE.jpg Donate - Emily is Getting a Furry Friend Emily is in need of a service dog for various reasons. A service dog will help her get to and from places mobility wise and help calm Emily’s nerves as she deals with increased anxiety around crowds and of course doctor appointments. A service dog will also help to detect Emily’s medical needs of anxiousness, seizures, episodes and migraine pain. A service dog will allow for more independence as she spends time "away" from her parents as Emily recently turned 20 and wants to be a young adult. In instances where Emily is struggling, the dog can come and alert her parents to any needs she has and they can assist Emily with her challenges. A service dog will be a companion who understands Emily and her unique obstacles. It also is someone who Emily can share and confide in; especially on those harder days as Emily has already endured 63 surgeries and counting. A service dog will love her unconditionally, but will also help her medically, physically and emotionally. https://thelittlegiantsfoundation.org/blog-impact daily 0.75 2025-05-09 https://thelittlegiantsfoundation.org/blog-impact/example-blog-post-1-25h87 monthly 0.5 2017-11-09 https://thelittlegiantsfoundation.org/blog-impact/example-blog-post-2-dbcyc monthly 0.5 2017-11-09 https://thelittlegiantsfoundation.org/our-story daily 0.75 2024-10-14 https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1556123100703-5T4RNO3ZGUPG7CIJ3R64/5I8A4342.jpg Our Story https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/bb17d5ff-2a92-462a-8505-e4a5351d5f88/LITTLE+GIANTS+BOARD+2021.jpg Our Story https://thelittlegiantsfoundation.org/events daily 0.75 2025-05-04 https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/04e2a449-98d5-4178-99ea-822c0eea2a00/HUFF+POST Events - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://thelittlegiantsfoundation.org/reports-and-articles daily 0.75 2021-04-29 https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1619540415818-FDLWNLG5OSMQAC8MXBA2/SIOD+%26+Teeth.png Reports and Articles - Dental Abnormalities in Schimke Immuno-osseous Dysplasia https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1619540574693-U2WQ2M4WRHCOJSWVQKSJ/SIOD+%26+penetrance+%26+heat+stress.png Reports and Articles - Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1619540740900-VKT75QOUDFKWVWDT7CKC/SIOD+%26+cancer.png Reports and Articles - SMARCAL 1 Deficiency Predisposes to Non-Hodgkin Lymphoma and Hypersensitivity to Genotoxic Agents in Vivo https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1619541195940-Z89XP4E8VB7C1KVNNKRX/SIOD+%26+artery+disease.png Reports and Articles - Reduced blastogenesis: a clue to the arteriosclerosis and emphysematous changes in Schimke immune-osseous dysplasia? https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1619541339677-H28N80Q631VYH5SB5HD7/Schimke+versus+non-Schimke+chronic+kidney+disease.png Reports and Articles - Schimke Versus Non-Schimke Chronic Kidney Disease: An Anthropometric Approach https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1619541597223-UEXTRYZO92RHZNMZJWRH/GeneReview+Schimke.png Reports and Articles - Schimke Immunoosseous Dysplasia https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1619541712955-Q2X398SC6TBE3H0OTQ8M/file.png Reports and Articles - Low renal but high extra renal phenotype variability in Schimke immuno-osseous dysplasia https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1619541947948-PZQC29674I8LSWVSHU81/Elizondo_et_al.png Reports and Articles - Schimke Immuno-Osseous Dysplasia: A Cell Autonomous Disorder? https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1619542239270-4TBHJ02UB84N2IMUENNC/Elastogenesis+%26+SIOD+Vascular+Disease.png Reports and Articles - Reduced blastogenesis: a clue to the arteriosclerosis and emphysematous changes in Schimke immune-osseous dysplasia? https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1619542440734-ND0P0A9HSCQ8RB4E2ZPD/Clewing+J+Med+Genet+2007.png Reports and Articles - Schimke immunodeficiency-ossesous dysplasia: a clinicopathological correlation https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1619542687664-XXRJC4DASKGGKZ9EZ9UA/2016+Morimoto+Orphanet+J+Rare+Disease+_+SIOD+Renal+Disease.png Reports and Articles - Increased Wnt and Notch signaling: a clue to the renal disease in Schimke immuno-osseous dysplasia? https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1619542817388-HJTJXJM8EGQ1ATMQ19CI/2016+Morimotot+Nucleus+_+Chromatin+changes+in+SIOD.png Reports and Articles - Chromatin changes in SMARCAL1 deficiency: A hypothesis for the gene expression alterations of Schimke immune-osseous dysplasia https://images.squarespace-cdn.com/content/v1/5cbf9540348cd933672d3732/1619543031334-TQODXUPUFLSFVK6YFXY2/0001-3765-aabc-201520140711.png Reports and Articles - New approaches to the treatment of orphan genetic disorders: Mitigating molecular pathologies using chemicals https://thelittlegiantsfoundation.org/doctors daily 0.75 2021-04-29 https://thelittlegiantsfoundation.org/partners-impact daily 0.75 2025-05-09 https://thelittlegiantsfoundation.org/contact-impact daily 0.75 2025-05-09 https://thelittlegiantsfoundation.org/impact-impact daily 0.75 2025-05-09 https://thelittlegiantsfoundation.org/press-impact daily 0.75 2025-05-09 https://thelittlegiantsfoundation.org/programs-impact daily 0.75 2025-05-09